Reaktion #700312

Reaktionsgleichung

4'-methoxyacetophenone

trimethylsilyl triflate

triethylamine

[(2-isopropylphenyl)thio]propanedioic acid

→

title compound

4-Hydroxy-3-[(2-isopropylphenyl)thio]-6-(4-methoxyphenyl)-2H-pyran-2-one

Lösungsmittel

methylene chloride

Reaktionsbedingungen

Vorschrift

The title compound was prepared by Method A using 4'-methoxyacetophenone (2.26 g, 15.1 mmol), trimethylsilyl triflate (3.5 mL, 18.1 mmol), triethylamine (4.26 mL, 30.6 mmol), methylene chloride (30 mL), and diethyl ester of [(2-isopropylphenyl)thio]propanedioic acid (3.11 g, 10.0 mmol) m.p. 221-223° C.; 1H NMR (400 MHz, DMSO-d6) δ 1.25 (d, 6H), 3.40 (m, 1H), 3.85 (s, 3H), 6.78 (s, 1H), 6.92 (m, 1H), 7.10 (m, 4H), 7.27 (m, 1H), 7.81 (d, 2H), 12.38 (brs, 1H).

Quelle