Reaktion #700306

Reaktionsgleichung

3', 5'-dimethylacetophenone

trimethylsilyl triflate

triethylamine

[(2-isopropylphenyl)thio]propanedioic acid

→

title compound

6-(3,5-Dimethylphenyl)-4-hydroxy-3-[(2-isopropylphenyl)- thio]-2H-pyran-2-one

Lösungsmittel

methylene chloride

Reaktionsbedingungen

Vorschrift

The title compound was prepared by Method A using 3', 5'-dimethylacetophenone (0.714 g, 4.83 mmol), trimethylsilyl triflate (1.12 mL, 5.79 mmol), triethylamine (1.34 mL, 9.66 mmol), methylene chloride (17 mL), and diethyl ester of [(2-isopropylphenyl)thio]propanedioic acid (1.00 g, 3.22 mmol) m.p. 154-155° C.; 1H NMR (400 MHz, DMSO-d6) δ 1.24 (d, 6H), 2.35 (s, 6H), 3.40 (m, 1H), 6.90 (d, 1H), 7.05 (t, 1H), 7.11 (dt, 2H), 7.20 (s, 1H), 7.27 (d, 1H), 7.45 (s, 2H).

Quelle