Reaktion #70029

ord-d78911145eaf423f9f96874f66545cd1

Reaktionsgleichung

CCOC(=O)CC(=O)N(c1ccc2[nH]cnc2c1)C(C(=O)NCC(C)(C)OC(=O)OC)c1cc(F)cc(F)c1F
ethyl 2-[(1H-benzo[d]imidazol-5-yl)[2,3,5-trifluorophenyl({2-[(methoxycarbonyl)oxy]-2-methylpropyl}carbamoyl)methyl]-carbamoyl]acetate
CC(C)(C)[O-].[K+]
potassium tert.-butoxide
→
CCOC(=O)C1C(=O)C(c2cc(F)cc(F)c2F)N(c2ccc3[nH]cnc3c2)C1=O
Ethyl 1-(1H-benzo[d]imidazol-5-yl)-2,4-dioxo-5-(2,3,5-trifluorophenyl)pyrrolidine-3-carboxylate

Edukte

CCOC(=O)CC(=O)N(c1ccc2[nH]cnc2c1)C(C(=O)NCC(C)(C)OC(=O)OC)c1cc(F)cc(F)c1F
ethyl 2-[(1H-benzo[d]imidazol-5-yl)[2,3,5-trifluorophenyl({2-[(methoxycarbonyl)oxy]-2-methylpropyl}carbamoyl)methyl]-carbamoyl]acetate
—
Intermediate 3
CC(C)(C)[O-].[K+]
potassium tert.-butoxide

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigeThe compound was synthesized
  2. 2
    Sonstigemay be prepared in accordance with the procedure

Vorschrift

The compound was synthesized starting from ethyl 2-[(1H-benzo[d]imidazol-5-yl)[2,3,5-trifluorophenyl({2-[(methoxycarbonyl)oxy]-2-methylpropyl}carbamoyl)methyl]-carbamoyl]acetate (which may be prepared in accordance with the procedure described for Intermediate 3; 0.153 g, 0.271 mmol) and potassium tert.-butoxide solution (1M, 0.542 ml, 0.542 mmol) according to the method described in step 2.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08530670B2uspto-grants-2013_09