Reaktion #700285

Reaktionsgleichung

4'-(4-pyridinylmethoxy)acetophenone

trimethylsilyltriflate

triethylamine

[(2-phenylethyl)thio]propanedioic acid

→

title compound

4-Hydroxy-3-[(2-phenylethyl)thio]-6[4-(4-pyridinylmethoxy)phenyl]-2H-pyran-2-one

Lösungsmittel

methylene chloride

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstige212° C.

Vorschrift

The title compound was prepared by Method A using 4'-(4-pyridinylmethoxy)acetophenone (2.00 g, 8.81 mmol), trimethylsilyltriflate (2.04 mL, 10.57 mmol), triethylamine (2.45 mL, 17.62 mmol), methylene chloride (22 mL), and diethyl ester of [(2-phenylethyl)thio]propanedioic acid (1.00 g, 3.37 mmol). m.p. dec. 212° C.; 1H NMR (400 MHz, DMSO-d6) δ2.73 (t, 2 H), 2.88 (t, 2 H), 5.29 (s, 2 H), 6.48 (s, 1 H), 7.18 (m, 5 H), 7.45 (d, 2 H), 7.74 (d, 2 H), 8.90 (d, 2 H).

Quelle