Reaktion #69981

Reaktionsgleichung

4-(4-bromophenyl)piperidin-4-ol

triethylamine

methanesulphonyl chloride

→

4-(4-bromophenyl)-1-(methanesulphonyl)piperidin-4-ol

Lösungsmittel

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   WaschenIt is washed with water
2. 2
   TrocknenThe organic phase is dried over sodium sulphate
3. 3
   Sonstigeevaporated under reduced pressure
4. 4
   SonstigeThe crude product obtained
5. 5
   Sonstigeis chromatographed on silica gel, elution

Vorschrift

1 g of 4-(4-bromophenyl)piperidin-4-ol is placed in 20 ml of dichloromethane. 0.65 ml of triethylamine and then 0.33 ml of methanesulphonyl chloride are added. The reaction mixture is stirred at ambient temperature for 2 h. It is washed with water and then with a saturated aqueous sodium chloride solution. The organic phase is dried over sodium sulphate and then evaporated under reduced pressure. The crude product obtained is chromatographed on silica gel, elution being carried out with a dichloromethane/methanol (99/1) solvent mixture. 1.1 g of 4-(4-bromophenyl)-1-(methanesulphonyl)piperidin-4-ol are obtained.

Quelle