Reaktion #699795

Reaktionsgleichung

4-bromo-3-methoxyphenol

potassium carbonate

n-propyl iodide

→

title compound

Ausbeute 88.0%

1-bromo-2-methoxy-4-propoxy-benzene

Ausbeute 88.0%

Lösungsmittel

acetone

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturto reflux overnight
2. 2
   Filtrationfilter
3. 3
   SonstigeRotovap to condense
4. 4
   Sonstigeevaporate the solvents
5. 5
   WaschenWash three times with 100 mL 3% potassium hydroxide
6. 6
   TrocknenDry the organic layer with magnesium sulfate
7. 7
   FiltrationFilter
8. 8
   SonstigePurify by chromatography and place under high vacuum

Vorschrift

Prepare a solution of 4-bromo-3-methoxyphenol (6.5 g, 32 mmole), and potassium carbonate (15 g) in acetone (250 mL) under argon. Add n-propyl iodide (9.0 g, 5.2 mL, 53 mmole) and heat to reflux overnight. Cool to room temperature and filter. Rotovap to condense and evaporate the solvents. Check by thin layer chromatagraphy (25% ethyl aceate/75% hexane). Wash three times with 100 mL 3% potassium hydroxide. Dry the organic layer with magnesium sulfate. Filter and rotovap. Purify by chromatography and place under high vacuum to obtain the title compound (6.9 g, 88%). Rf=0.60 (EtOAc/hexane; 25:75).

Quelle