Reaktion #69969

Reaktionsgleichung

Water

methanesulphonyl chloride

1-(4-bromophenyl)piperazine

triethylamine

→

1-(4-Bromophenyl)-4-(methanesulphonyl)piperazine

Lösungsmittel

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Waschenthe organic phase is washed twice with water
2. 2
   Trocknendried over magnesium sulphate
3. 3
   Sonstigethe solvent is evaporated under reduced pressure
4. 4
   Sonstigeto result in 26.2 g of 1-(4-bromophenyl)-4-(methanesulphonyl)piperazine
5. 5
   Sonstigeas is without other purification

Vorschrift

7.7 ml of methanesulphonyl chloride are added to a solution of 20 g of 1-(4-bromophenyl)piperazine and 17.34 ml of triethylamine in 394 ml of dichloromethane. The reaction medium is stirred at ambient temperature for 4 h. Water is subsequently added and the organic phase is washed twice with water and dried over magnesium sulphate and then the solvent is evaporated under reduced pressure to result in 26.2 g of 1-(4-bromophenyl)-4-(methanesulphonyl)piperazine. The product is subsequently used as is without other purification.

Quelle