Reaktion #699661

Reaktionsgleichung

2,3-dihydro-4-fluoro-5-methoxy-N-(4-pyridinyl)-1H-isoindol-2-amine

hydrobromic acid

→

product

Ausbeute 69.0%

2,3-Dihydro-4-fluoro-2-(-4-pyridinylamino)-1 H-isoindol-5-ol hydrobromide

Ausbeute 69.0%

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturunder reflux, for 5 hrs
2. 2
   TemperaturThe mixture was cooled to approximately 10° C.
3. 3
   Filtrationfiltered
4. 4
   WaschenThe filter cake was washed with cold water
5. 5
   Sonstigedried under vacuum at 80° C.

Vorschrift

A solution of 2,3-dihydro-4-fluoro-5-methoxy-N-(4-pyridinyl)-1H-isoindol-2-amine (3.25 g) in 48% hydrobromic acid (25 ml) was stirred, under reflux, for 5 hrs. The reaction mixture was diluted with water and stirred at ambient temperature overnight. The mixture was cooled to approximately 10° C. and filtered. The filter cake was washed with cold water and dried under vacuum at 80° C. to give 2.8 g (69%) of product. Recrystallization from water gave the analytical sample, mp. >250° C., dried at 80° C. under vacuum.

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