Reaktion #698958

Reaktionsgleichung

benzo-1,2,3-thiadiazole-7-carboxylic acid

dimethylformamide

thionyl chloride

→

Benzo-1,2,3-thiadiazole-7-carbonyl chloride

Lösungsmittel

toluene

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturthe solution is cooled
2. 2
   Filtrationfiltered over a little Hyflo
3. 3
   Waschenthe residue is rinsed with toluene
4. 4
   Sonstigethe filtrate is evaporated
5. 5
   Sonstige297 g (93%) of crude acid chloride, which can be further reacted directly
6. 6
   Sonstigeresult

Vorschrift

290 g of benzo-1,2,3-thiadiazole-7-carboxylic acid are suspended in 1.6 l of toluene, 3.5 ml of dimethylformamide and 129 ml of thionyl chloride are added and the mixture is stirred at 80-90° C., the suspension turning into a solution as the release of gas progresses. When the reaction has ended, the solution is cooled and filtered over a little Hyflo, the residue is rinsed with toluene and the filtrate is evaporated. 297 g (93%) of crude acid chloride, which can be further reacted directly, result.

Quelle