Reaktion #698321

ord-b46d223629d840bf9c83f1f44c2d76e3

Reaktionsgleichung

CN(C)Cc1cc2c(o1)CN(C(=O)c1ccc3c(c1)C(=O)c1ccccc1C3=O)CC2
N,N-Dimethyl-[6-(anthraquinone-2-carbonyl)-4,5,6,7-tetrahydrofuro[2,3-c]pyridin-2-ylmethyl]amine
Cl
hydrogen chloride
→
CN(C)Cc1cc2c(o1)CN(C(=O)c1ccc3c(c1)C(=O)c1ccccc1C3=O)CC2.Cl
desired product
CN(C)Cc1cc2c(o1)CN(C(=O)c1ccc3c(c1)C(=O)c1ccccc1C3=O)CC2.Cl
N,N-dimethyl-[6-(anthraquinone-2-carbonyl)-4,5,6,7-tetrahydrofuro[2,3-c]pyridin-2-ylmethyl]amine hydrochloride

Edukte

CN(C)Cc1cc2c(o1)CN(C(=O)c1ccc3c(c1)C(=O)c1ccccc1C3=O)CC2
N,N-Dimethyl-[6-(anthraquinone-2-carbonyl)-4,5,6,7-tetrahydrofuro[2,3-c]pyridin-2-ylmethyl]amine
Cl
hydrogen chloride

Reagenzien

Keine

Lösungsmittel

CO
methanol
CCOC(C)=O
ethyl acetate

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    EinengenAfter this mixture was concentrated
  2. 2
    Sonstigethe resulting solid was recrystallized from diethyl ether-ethanol

Vorschrift

N,N-Dimethyl-[6-(anthraquinone-2-carbonyl)-4,5,6,7-tetrahydrofuro[2,3-c]pyridin-2-ylmethyl]amine 0.227 g was dissolved in 2 ml of methanol; hydrogen chloride in ethyl acetate was added in excess, followed by stirring. After this mixture was concentrated, the resulting solid was recrystallized from diethyl ether-ethanol to yield the desired product.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05998433uspto-grants-1999_12