Reaktion #698309

ord-6c89ced785234b3ebdbbb49148fd4c2e

Reaktionsgleichung

CN(C)Cc1cc2c(o1)CN(C(=O)c1ccc(-c3ccccc3)cc1)CC2
N,N-Dimethyl-[6-(4-phenylbenzoyl)-4,5,6,7-tetrahydrofuro[2,3-c]pyridin-2-ylmethyl]amine
Cl
hydrogen chloride
→
CN(C)Cc1cc2c(o1)CN(C(=O)c1ccc(-c3ccccc3)cc1)CC2.Cl
desired product
CN(C)Cc1cc2c(o1)CN(C(=O)c1ccc(-c3ccccc3)cc1)CC2.Cl
N,N-dimethyl-[6-(4-phenylbenzoyl)-4,5,6,7-tetrahydrofuro[2,3-c]pyridin-2-ylmethyl]amine hydrochloride

Edukte

CN(C)Cc1cc2c(o1)CN(C(=O)c1ccc(-c3ccccc3)cc1)CC2
N,N-Dimethyl-[6-(4-phenylbenzoyl)-4,5,6,7-tetrahydrofuro[2,3-c]pyridin-2-ylmethyl]amine
Cl
hydrogen chloride

Reagenzien

Keine

Lösungsmittel

CO
methanol
CCOC(C)=O
ethyl acetate

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    EinengenAfter concentration
  2. 2
    Sonstigethe crude product recrystallized from ethanol-diethyl ether

Vorschrift

N,N-Dimethyl-[6-(4-phenylbenzoyl)-4,5,6,7-tetrahydrofuro[2,3-c]pyridin-2-ylmethyl]amine 0.180 g was dissolved in 2 ml of methanol; hydrogen chloride in ethyl acetate was added in excess, followed by stirring. After concentration, the crude product recrystallized from ethanol-diethyl ether to yield the desired product.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05998433uspto-grants-1999_12