Reaktion #69819

Reaktionsgleichung

HCl

tert-butyl 2-(naphthalen-1-ylmethyl)-1-oxo-2,9-diazaspiro[5.5]undecane-9-carboxylate

→

2-(naphthalen-1-ylmethyl)-2,9-diazaspiro[5.5]undecan-1-one hydrochloride

Ausbeute 87.0%

Lösungsmittel

CH2Cl2

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe volatiles were evaporated

Vorschrift

HCl (4M in dioxane, 5 ml) was added to a solution of tert-butyl 2-(naphthalen-1-ylmethyl)-1-oxo-2,9-diazaspiro[5.5]undecane-9-carboxylate (377 mg, 0.9 mmol) in CH2Cl2 (2 ml) and the mixture was stirred at rt for 18 h. The volatiles were evaporated to afford 270 mg (87%) of crude 2-(naphthalen-1-ylmethyl)-2,9-diazaspiro[5.5]undecan-1-one hydrochloride, which was used without further purification.

Quelle