Reaktion #697353

Reaktionsgleichung

N-methylpyrrolidone

2-amino-3,5,6-trifluoropyridine

p-methoxybenzylamine

→

title compound

Ausbeute 64.4%

2-amino-3,5-difluoro-6-(p-methoxybenzylamino)-pyridine

Ausbeute 64.4%

Lösungsmittel

chloroform

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturto cool
2. 2
   Waschenthe solution was washed three times with 500 ml of distilled water
3. 3
   TrocknenThe chloroform layer was dried over anhydrous magnesium sulfate
4. 4
   Einengenconcentrated under reduced pressure

Vorschrift

To 10 ml of N-methylpyrrolidone were added 3.90 g of 2-amino-3,5,6-trifluoropyridine and 7.60 g of p-methoxybenzylamine, and the mixture was stirred under nitrogen atmosphere at 140° C. for one day and allowed to cool. To the solution was added 50 ml of chloroform, and the solution was washed three times with 500 ml of distilled water. The chloroform layer was dried over anhydrous magnesium sulfate and concentrated under reduced pressure, and the residue was subjected to chromatography (silica gel, 32 g; eluent: chloroform) to obtain 4.50 g of the title compound as a pale yellow crude oil.

Quelle