Reaktion #697252

ord-7f072b296ace4bb2ad55cee16defa987

Reaktionsgleichung

COC(=O)C1C(=O)N(C)c2ccc(C3(C)OCCO3)cc21
1-methyl-5-(2-methyl-[1,3]dioxolan-2-yl)-2-oxo-2,3-dihydro-1H-indole-3-carboxylic acid methyl ester
Nc1cccc(C(=O)Nc2ccc(Br)cc2)c1
3-amino-N-(4-bromo-phenyl)-benzamide
→
CC(=O)c1ccc2c(c1)C(C(=O)Nc1cccc(C(=O)Nc3ccc(Br)cc3)c1)C(=O)N2C
5-Acetyl-1-methyl-2-oxo-2,3-dihydro-1H-indole-3-carboxylic acid [3-(4-bromophenylcarbamoyl)-phenyl]-amide

Edukte

COC(=O)C1C(=O)N(C)c2ccc(C3(C)OCCO3)cc21
1-methyl-5-(2-methyl-[1,3]dioxolan-2-yl)-2-oxo-2,3-dihydro-1H-indole-3-carboxylic acid methyl ester
Nc1cccc(C(=O)Nc2ccc(Br)cc2)c1
3-amino-N-(4-bromo-phenyl)-benzamide

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigePurified by flash-chromatography (hexanes/acetone, 1:1)

Vorschrift

Prepared as in Example 1 from 1-methyl-5-(2-methyl-[1,3]dioxolan-2-yl)-2-oxo-2,3-dihydro-1H-indole-3-carboxylic acid methyl ester and 3-amino-N-(4-bromo-phenyl)-benzamide. Purified by flash-chromatography (hexanes/acetone, 1:1).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05998463uspto-grants-1999_12