Reaktion #697250

ord-5135fb3f47c14e0582bed7be8351239d

Reaktionsgleichung

CCOC(=O)C1C(=O)N(CC)c2ccc(C(=O)c3ccccc3)cc21
5-benzoyl-1-ethyl-2-oxo-2,3-dihydro-1H-indole-3-carboxylic acid ethyl ester
Nc1cccc(C(=O)Nc2ccc(Br)cc2)c1
3-amino-N-(4-bromo-phenyl)-benzamide
→
CCN1C(=O)C(C(=O)Nc2cccc(C(=O)Nc3ccc(Br)cc3)c2)c2cc(C(=O)c3ccccc3)ccc21
5-Benzoyl-1-ethyl-2-oxo-2,3-dihydro-1H-indole-3-carboxylic acid [3-(4-bromophenylcarbamoyl)-phenyl]-amide

Edukte

CCOC(=O)C1C(=O)N(CC)c2ccc(C(=O)c3ccccc3)cc21
5-benzoyl-1-ethyl-2-oxo-2,3-dihydro-1H-indole-3-carboxylic acid ethyl ester
Nc1cccc(C(=O)Nc2ccc(Br)cc2)c1
3-amino-N-(4-bromo-phenyl)-benzamide

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigePrepared as in Example 1, Step A
  2. 2
    SonstigePurified by flash-chromatography (hexanes/acetone, 1:1)

Vorschrift

Prepared as in Example 1, Step A, from 5-benzoyl-1-ethyl-2-oxo-2,3-dihydro-1H-indole-3-carboxylic acid ethyl ester (U.S. Pat. No. 4,686,224) and 3-amino-N-(4-bromo-phenyl)-benzamide. Purified by flash-chromatography (hexanes/acetone, 1:1) followed by trituration in ethyl acetate/hexanes. mp 139-142° C.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05998463uspto-grants-1999_12