Reaktion #697248

ord-068573fb94454ce0ab7005f32e0e8adf

Reaktionsgleichung

CCN1C(=O)C(C(=O)OC)c2cc(C3(C)OCCO3)ccc21
1-ethyl-5-(2-methyl-[1,3]dioxolan-2-yl)-2-oxo-2,3-dihydro-1H-indole-3-carboxylic acid methyl ester
Nc1cccc(C(=O)Nc2ccc(I)cc2)c1
3-amino-N-(4-iodo-phenyl)-benzamide
→
CCN1C(=O)C(C(=O)Nc2cccc(C(=O)Nc3ccc(I)cc3)c2)c2cc(C(C)=O)ccc21
5-Acetyl-1-ethyl-2-oxo-2,3-dihydro-1H-indole-3-carboxylic acid [3-(4-iodophenylcarbamoyl)-phenyl]-amide

Edukte

CCN1C(=O)C(C(=O)OC)c2cc(C3(C)OCCO3)ccc21
1-ethyl-5-(2-methyl-[1,3]dioxolan-2-yl)-2-oxo-2,3-dihydro-1H-indole-3-carboxylic acid methyl ester
Nc1cccc(C(=O)Nc2ccc(I)cc2)c1
3-amino-N-(4-iodo-phenyl)-benzamide

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Prepared as in Example 1 from 1-ethyl-5-(2-methyl-[1,3]dioxolan-2-yl)-2-oxo-2,3-dihydro-1H-indole-3-carboxylic acid methyl ester and 3-amino-N-(4-iodo-phenyl)-benzamide. mp 205-210° C. Calculated for C26H22IN3O4 : C 55.04; H 3.91; N 7.41; found C 55.13; H 4.04; N 7.12.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05998463uspto-grants-1999_12