Reaktion #697244

ord-4e61774953224f4b945feb603c693ad9

Reaktionsgleichung

CCN1C(=O)C(C(=O)OC)c2cc(C3(C)OCCO3)ccc21
1-ethyl-5-(2-methyl-[1,3]dioxolan-2-yl)-2-oxo-2,3-dihydro-1H-indole-3-carboxylic acid methyl ester
Nc1cccc(C(=O)Nc2ccc(F)cc2)c1
3-amino-N-(4-fluoro-phenyl)-benzamide
→
CCN1C(=O)C(C(=O)Nc2cccc(C(=O)Nc3ccc(F)cc3)c2)c2cc(C(C)=O)ccc21
5-Acetyl-1-ethyl-2-oxo-2,3-dihydro-1H-indole-3-carboxylic acid [3-(4-fluorophenylcarbamoyl)-phenyl]-amide

Edukte

CCN1C(=O)C(C(=O)OC)c2cc(C3(C)OCCO3)ccc21
1-ethyl-5-(2-methyl-[1,3]dioxolan-2-yl)-2-oxo-2,3-dihydro-1H-indole-3-carboxylic acid methyl ester
Nc1cccc(C(=O)Nc2ccc(F)cc2)c1
3-amino-N-(4-fluoro-phenyl)-benzamide

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigeRecrystallized from ethyl acetate-hexanes-benzene

Vorschrift

Prepared as in Example 1 from 1-ethyl-5-(2-methyl-[1,3]dioxolan-2-yl)-2-oxo-2,3-dihydro-1H-indole-3-carboxylic acid methyl ester and 3-amino-N-(4-fluoro-phenyl)-benzamide. Recrystallized from ethyl acetate-hexanes-benzene. Calculated for C26H22FN3O4 : C 67.97; H 4.83; N 9.15; found C 68.34; H 5.31; N 8.80.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05998463uspto-grants-1999_12