Reaktion #69705

Reaktionsgleichung

2-(2,4-bis-benzyloxy-5-isopropyl-benzoyl)-2,3-dihydro-1H-isoindole-5-carboxylic acid methyl ester

→

2-(2,4-bis-benzyloxy-5-isopropyl-benzoyl)-2,3-dihydro-1H-isoindole-5-carboxylic acid

Ausbeute 67.1%

Lösungsmittel

methanol

NaOH

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethen evaporated
2. 2
   Filtrationthe solid collected by filtration
3. 3
   Waschenwashed with water
4. 4
   Sonstigesucked dry

Vorschrift

A solution of 2-(2,4-bis-benzyloxy-5-isopropyl-benzoyl)-2,3-dihydro-1H-isoindole-5-carboxylic acid methyl ester (390 mg) in methanol (10 ml) and 2M NaOH (10 ml) was heated at 50° C. for 48 hours then evaporated. The residue was acidified with 2M HCl, the solid collected by filtration, washed with water and sucked dry to give 255 mg of 2-(2,4-bis-benzyloxy-5-isopropyl-benzoyl)-2,3-dihydro-1H-isoindole-5-carboxylic acid as a white solid. [M+H]+ 520.

Quelle