Reaktion #69686

Reaktionsgleichung

3-hydroxyphthalic anhydride

4-methoxybenzylamine

acetic acid

→

title compound

Ausbeute 81.1%

Hydroxy-2-(4-methoxy-benzyl)-isoindole-1,3-dione

Ausbeute 81.1%

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturto cool
2. 2
   FiltrationThe white solid was collected by filtration
3. 3
   Waschenwashed well with water
4. 4
   Sonstigedried

Vorschrift

A mixture of 3-hydroxyphthalic anhydride (543 mg, 3.31 mmol), 4-methoxybenzylamine (0.43 mL, 3.31 mmol) and acetic acid (3 mL) was heated at 100° C. for 4 hours. The mixture was allowed to cool and diluted with water (20 mL). The white solid was collected by filtration, washed well with water and dried to give the title compound (760 mg, 81%). 1H NMR (DMSO-d6) 11.03 (1H, s), 7.61 (1H, dd), 7.28 (1H, d), 7.23-7.19 (3H, m), 6.89-6.86 (2H, m), 4.63 (2H, s), 3.71 (3H, s). MS: [M−H+] 282.

Quelle