Reaktion #69632

Reaktionsgleichung

ammonium chloride

ethanol

2,3-dichloro-6-nitrobenzaldehyde

sodium borohydride

→

2,3-dichloro-6-nitrobenzyl alcohol

Lösungsmittel

tetrahydrofuran

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionthe solution was extracted three times with EtOAc
2. 2
   TrocknenThe combined organic layers were dried (MgSO4)
3. 3
   Einengenconcentrated

Vorschrift

To a solution of 2,3-dichloro-6-nitrobenzaldehyde (7.62 g, 34.9 mmol) in tetrahydrofuran (75 mL) was added sodium borohydride (1.31 g, 34.9 mmol) followed by ethanol (1.75 mL), and the mixture was stirred for 1.5 hours. Saturated aqueous ammonium chloride (75 mL) was added, and the solution was extracted three times with EtOAc. The combined organic layers were dried (MgSO4) and then concentrated to give 2,3-dichloro-6-nitrobenzyl alcohol, as an oil which crystallised, 7.62 g (98%).

Quelle