Reaktion #69629

Reaktionsgleichung

toluene

compound XIX

2,3-dichloro-6-nitrobenzaldehyde

sodium borohydride

→

compound XX

2,3-dichloro-6-nitrobenzyl alcohol

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Waschenwashed with water
2. 2
   SonstigeAfter removing the aqueous layer the organic layer
3. 3
   Sonstigeis azeotropically dried
4. 4
   Einengenconcentrated

Vorschrift

To form 2,3-dichloro-6-nitrobenzylalcohol (compound XX) from 2,3-dichloro-6-nitro benzaldehyde (compound XIX), compound XIX is preferably solubilized in a solvent or solvent mixture such as toluene and methanol. The solution of compound XIX is added to a reducing solution such as sodium borohydride in an organic solvent over a period of time to maintain a reaction temperature below about 40° C., preferably 25° C. The reaction is preferably stirred for 24 hours at room temperature under nitrogen and then washed with water. After removing the aqueous layer the organic layer is azeotropically dried and concentrated forming 2,3-dichloro-6-nitrobenzylalcohol (compound XX).

Quelle