Reaktion #6954

Reaktionsgleichung

2-cyano-3-cyclohexyl-3-oxo-propionic acid ethyl ester

→

3-Cyclohexyl-3-oxo-propionitrile

Lösungsmittel

DMSO water

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe reaction mixture was partitioned between ether and 1N HCl
2. 2
   Trocknenthe organic phase was dried with MgSO4
3. 3
   Sonstigethe solvent removed under reduced pressure

Vorschrift

A solution of 2-cyano-3-cyclohexyl-3-oxo-propionic acid ethyl ester in DMSO:water (10:1) was stirred at 120° C. for 2 hours. The reaction mixture was partitioned between ether and 1N HCl, the organic phase was dried with MgSO4 and the solvent removed under reduced pressure.

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