Reaktion #6945

Reaktionsgleichung

4-acetyl-3-methyl-5-methylsulfanyl-thiophene-2-carbonitrile

DMF-DMA

→

desired product

4-(3-Dimethylamino-acryloyl)-3-methyl-5-methylsulfanyl-thiophene-2-carbonitrile

Lösungsmittel

acetonitrile

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturthe resulting mixture heated
2. 2
   Temperaturat reflux for 18 hours
3. 3
   EinengenThe reaction was concentrated
4. 4
   Sonstigethe residue triturated with diethyl ether (20 mL)
5. 5
   FiltrationThe suspension was filtered
6. 6
   Waschenwashed with ether

Vorschrift

To a solution of 4-acetyl-3-methyl-5-methylsulfanyl-thiophene-2-carbonitrile (10 mmol) in acetonitrile (5 mL) was added DMF-DMA (2 mL) and the resulting mixture heated at reflux for 18 hours. The reaction was concentrated and the residue triturated with diethyl ether (20 mL). The suspension was filtered and washed with ether to afford the desired product as a yellow solid.

Quelle