Reaktion #694165

Reaktionsgleichung

Trans-5-amino-2-diphenylmethyl-tetrahydropyran

Cis-(6-benzhydryl-tetrahydropyran-3-yl)-amine

3,4-difluorobenzaldehyde

acetic acid

NaCNBH3

→

compound 16j

Ausbeute 80.3%

Cis-(6-benzhydryl-tetrahydropyran-3-yl)-(3,4-difluoro-benzyl)-amine

Ausbeute 80.3%

Lösungsmittel

1,2-dichloroethane

methanol

Reaktionsbedingungen

Vorschrift

Trans-5-amino-2-diphenylmethyl-tetrahydropyran 15 (0.1 g, 0.38 mmol) was reacted with 3,4-difluorobenzaldehyde (0.055 g, 0.38 mmol) in the presence of glacial acetic acid (0.023 g, 0.38 mmol) in 1,2-dichloroethane (20 ml), and NaCNBH3 (0.03 g, 0.45 mmol) in methanol (5 ml) (Procedure D) to give compound 16j (0.12 g, 80%).

Quelle