Reaktion #69360

Reaktionsgleichung

allylamine

5-chloro-thiophene-2-carbonyl chloride

→

N-allyl-5-chloro-2-thiophenecarboxamide

Lösungsmittel

pyridine

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturIce-cooling
2. 2
   Sonstigeis removed
3. 3
   Einengenconcentrated under reduced pressure
4. 4
   Filtrationthe solid is filtered off
5. 5
   SonstigeThe crude product is purified by flash chromatography over silica gel (dichloromethane)

Vorschrift

An ice-cooled solution of 2.63 ml (35 mmol) of allylamine in 14.2 ml of absolute pyridine and 14.2 ml of absolute THF is admixed dropwise with 5-chloro-thiophene-2-carbonyl chloride (7.61 g, 42 mmol). Ice-cooling is removed and the mixture is stirred at room temperature for 3 h and then concentrated under reduced pressure. The residue is admixed with water and the solid is filtered off. The crude product is purified by flash chromatography over silica gel (dichloromethane).

Quelle