Reaktion #69357

Reaktionsgleichung

4-(4-morpholin-3-onyl)nitrobenzene

hydrogen

→

product

Ausbeute 37.8%

4-(4-Morpholin-3-onyl)aniline

Ausbeute 37.8%

Lösungsmittel

tetrahydrofuran

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe catalyst is filtered off
2. 2
   workup.DISTILLATIONthe solvent is then distilled off under reduced pressure
3. 3
   Sonstigethe product is purified by crystallization from ethyl acetate

Vorschrift

In an autoclave, 63 g (0.275 mol) of 4-(4-morpholin-3-onyl)nitrobenzene are dissolved in 200 ml of tetrahydrofuran, admixed with 3.1 g of Pd/C (5% ig) and hydrogenated at 70° C. and a hydrogen pressure of 50 bar for 8 h. The catalyst is filtered off, the solvent is then distilled off under reduced pressure and the product is purified by crystallization from ethyl acetate. 20 g of product are obtained as a colourless to bluish solid, in a yield of 37.6% of theory.

Quelle