Reaktion #692007

Reaktionsgleichung

3-Trifluoromethyl-2-pyrazine carboxylic acid

3-isobutyl-4-[2,2,2-trifluoro-1-(trifluoromethyl)ethyl]aniline

2-chloro-1-methylpyridinium iodide

triethylamine

→

desired compound

Ausbeute 62.0%

N-{3-isobutyl-4-[2,2,2-trifluoro-1-(trifluoromethyl)ethyl]pheny}-3-trifluoromethylpyrazine-2-carboxamide

Ausbeute 62.0%

Lösungsmittel

ethyl acetate

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturrefluxed
2. 2
   Temperaturunder heating for 2 hours
3. 3
   Waschenby washing with water
4. 4
   TrocknenThe organic layer was dried over magnesium sulfate anhydride
5. 5
   Einengenconcentrated under reduced pressure
6. 6
   Sonstigethe solution was purified

Vorschrift

3-Trifluoromethyl-2-pyrazine carboxylic acid (192 mg, 1 mmol), 3-isobutyl-4-[2,2,2-trifluoro-1-(trifluoromethyl)ethyl]aniline (199 mg, 1 mmol), 2-chloro-1-methylpyridinium iodide (255 mg, 1 mmol) and triethylamine (303 mg, 3 mmol) were dissolved in THF (10 ml) and refluxed under heating for 2 hours. The reaction solution was diluted with ethyl acetate, followed by washing with water. The organic layer was dried over magnesium sulfate anhydride, and concentrated under reduced pressure, and then the solution was purified by using silica gel chromatography (hexane:ethyl acetate=2:1) to obtain 293 mg of the desired compound as paste state.

Quelle