Reaktion #6920

Reaktionsgleichung

2-Bromothiazole-4-carbaldehyde

ethylene glycol

→

product

Ausbeute 74.7%

2-Bromo-4-(1,3-dioxolan-2-yl) thiazole

Ausbeute 74.7%

Lösungsmittel

toluene

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigefitted, for 18 hr
2. 2
   EinengenThe product was concentrated
3. 3
   Sonstigepurified by column chromatography (15% ethyl acetate /hexane)

Vorschrift

2-Bromothiazole-4-carbaldehyde (6.56 g, 34.17 mmol) [A. T. Ung, S. G. Pyne/Tetrahedron: Asymmetry 9 (1998) 1395–1407] and ethylene glycol (5.72 ml, 102.5 mmol) were heated under reflux in toluene (50 ml), with a Dean and Stark trap fitted, for 18 hr. The product was concentrated and purified by column chromatography (15% ethyl acetate /hexane) to give the product as a yellow solid (6.03 g); m/z 236,238.

Quelle