Reaktion #6915

Reaktionsgleichung

7-Amino-quinazolin-4-one

potassium iodide

sodium nitrite

→

title compound

Ausbeute 17.8%

7-Iodoquinazoline-4-one

Ausbeute 17.8%

Lösungsmittel

HCl

water

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturcooled in an ice bath
2. 2
   Sonstigepartitioned between ethyl acetate and sodium thiosulphate
3. 3
   SonstigeThe organic phase was dried
4. 4
   Einengenconcentrated in vacuo

Vorschrift

7-Amino-quinazolin-4-one (R. Dempsy and E. Skito, Biochemistry, 30, 1991, 8480) (1.61 g) was suspended in 6N HCl (20 ml) and cooled in an ice bath. A solution of sodium nitrite (0.75 g) in water (10 ml) was added dropwise over 15 minutes. After a further 10 minutes, a solution of potassium iodide (1.66 g) in water (5 ml) was added dropwise. The mixture was warmed to 20° C. and after 3 hours partitioned between ethyl acetate and sodium thiosulphate. The organic phase was dried and concentrated in vacuo to give the title compound (0.485 g); m/z (M+1+) 271.

Quelle