Reaktion #69128

Reaktionsgleichung

(R)-tert-butyl 1-(4-hydroxyphenyl)ethylcarbamate

→

title compound

Ausbeute 61.0%

(R)-tert-butyl 1-(4-hydroxycyclohexyl)ethylcarbamate

Ausbeute 61.0%

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe rhodium catalyst was filtered off
2. 2
   Einengenthe mother liquors were concentrated in vacuo
3. 3
   SonstigeThe residue was purified on silica gel by flash column chromatography

Vorschrift

(R)-tert-butyl 1-(4-hydroxyphenyl)ethylcarbamate (described in the literature: WO 2007035154 (A1)) (100 mg, 0.4214 mmol) was dissolved in methanol (5 mL). A methanolic (5 mL) solution of rhodium on alumina (10 Wt %, 10 mg) was added. The reaction mixture was place under a hydrogen atmosphere and stir at room temperature for 18 hours. The rhodium catalyst was filtered off and the mother liquors were concentrated in vacuo. The residue was purified on silica gel by flash column chromatography to afford the title compound (62 mg, 61% yield).

Quelle