Reaktion #6910

Reaktionsgleichung

product

N-[1-(6-cyanoquinolin-2-yl)pyrrolidin-3-yl]-2,2-dimethylpropanamide

hydroxyl amine hydrochloride

sodium carbonate

→

N-(1-{6-[(Hydroxyamino)(imino)methyl]quinolin-2-yl}pyrrolidin-3-yl)-2,2-dimethylpropanamide

Lösungsmittel

dichloromethane

water

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Waschenwashed twice with brine
2. 2
   Trocknendried over sodium sulfate
3. 3
   Filtrationfiltered through a fritted funnel
4. 4
   Sonstigethe volatiles were removed under vacuum
5. 5
   SonstigeThis provided the product, MS
6. 6
   Sonstigem/z 356, which was used in the next step without further purification

Vorschrift

A mixture of the product of Step D (60 mg; 0.1863 mmol), hydroxyl amine hydrochloride (3 eq.), sodium carbonate (4 eq.) in 1.5 mL water and 2.5 mL ethanol was heated to 90° C. for 6 h. The mixture was diluted with dichloromethane, washed twice with brine, dried over sodium sulfate, filtered through a fritted funnel and the volatiles were removed under vacuum. This provided the product, MS: m/z 356, which was used in the next step without further purification.

Quelle