Reaktion #69099

Reaktionsgleichung

2,4-diamino-6-ethyl-5-(3-(2-(2-carboxyethyl)phenoxy)propoxy)pyrimidine

HCl

→

titled compound

2,4-diamino-6-ethyl-5-(3-(2-(2-carboxyethyl)phenoxy)propoxy)pyrimidine hydrochloride

Lösungsmittel

water

Reaktionsbedingungen

Vorschrift

To a suspension of 2,4-diamino-6-ethyl-5-(3-(2-(2-carboxyethyl)phenoxy)propoxy)pyrimidine (0.3604 g, 1 mmol) in water (1 mL) was added one equivalent of concentrated HCl. The titled compound was obtained, after trituration of the reaction mixture with diethyl ether, as a white crystalline solid (0.3770 g, 95%). 1H NMR (400 MHz, DMSO-d6): 1.12 (3H, t, J=7.5 Hz), 2.22 (2H, t, J=5.8 Hz), 2.44-2.52 (4H, m), 2.78 (2H, t, J=7.5 Hz), 3.89 (2H, t, J=5.9 Hz), 4.14 (2H, t, J=5.5 Hz), 6.85 (1H, t, J=7.3 Hz), 6.98 (1H, d, J=8.1 Hz), 7.14-7.19 (2H, m) 7.41 (2H, s), 7.85 (1H, s), 8.31 (1H, s), 12.11 (1H, bs), 12.54 (1H, s).

Quelle