Reaktion #69085

Reaktionsgleichung

2,4-diamino-6-ethyl-5-(3-(2-methylquinolin-4-yloxy)propoxy)pyrimidine

hydrochloric acid

→

solid

Ausbeute 92.0%

2,4-diamino-6-ethyl-5-(3-(2-methylquinolin-4-yloxy)propoxy)pyrimidine monohydrochloride

Ausbeute 92.0%

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeAfter evaporation of solvent and trituration with diethyl ether

Vorschrift

To a stirring suspension of 2,4-diamino-6-ethyl-5-(3-(2-methylquinolin-4-yloxy)propoxy)pyrimidine (0.353 g, 1 mmol) in methanol (10 mL) was added one equivalent of hydrochloric acid at 25° C. After evaporation of solvent and trituration with diethyl ether, product was obtained as light yellow solid (0.3587 g, 92%). mp: 194-196° C. (dec.). 1H NMR (400 MHz, DMSO-d6): 0.99 (3H, t, J=7.5 Hz), 2.36 (2H, m), 2.44 (2H, q, J=7.5 Hz), 2.65 (3H, s), 3.97 (2H, t, J=6.0 Hz), 4.45 (2H, t, J=5.6 Hz), 7.09 (1H, s), 7.40 (2H, bs), 7.54 (2H, t, J=7.5 Hz), 7.75 (1H, t, J=7.8 Hz), 7.93 (2H, m), 8.14 (2H, m), 12.55 (1H, bs).

Quelle