Reaktion #69080

Reaktionsgleichung

2,4-diamino-6-ethyl-5-(3-(6-chloroquinolin-4-yloxy)propoxy)pyrimidine

HCl

→

titled compound

2,4-diamino-6-ethyl-5-(3-(6-chloroquinolin-4-yloxy)propoxy)pyrimidine dihydrochloride

Lösungsmittel

methanol

Reaktionsbedingungen

Vorschrift

To a suspension of 2,4-diamino-6-ethyl-5-(3-(6-chloroquinolin-4-yloxy)propoxy)pyrimidine (0.5608 g, 1.5 mmol) in methanol (1 mL) was added two equivalents of concentrated HCl. The titled compound was obtained, after trituration of the reaction mixture with diethyl ether, as a off-white crystalline solid (0.6366 g, 95%). 1H NMR (500 MHz, DMSO-d6): 1.09 (3H, t, J=7.7 Hz), 2.43 (2H, m), 2.48 (2H, m), 3.99 (2H, t, J=6.2 Hz), 4.70 (2H, t, J=5.9 Hz), 7.55 (2H, bs), 7.64 (1H, d, J=6.6 Hz), 7.95 (1H, s), 3.15 (1H, dd, J=9.1, 2.4 Hz), 8.37 (2H, m), 8.41 (1H, d, J=9.1 Hz), 9.22 (1H, d, J=6.5 Hz), 12.80 (1H, s).

Quelle