Reaktion #690592

Reaktionsgleichung

2-allyl-4-(trifluoromethyl)phenol

→

2-propyl-4-(trifluoromethyl)phenol

Lösungsmittel

EtOH

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe catalyst was removed by filtration
2. 2
   EinengenThe filtrate was concentrated under reduced pressure
3. 3
   Sonstigethe residue was purified by silica gel flash chromatography (EtOAc/hexane (v/v) 1:10)

Vorschrift

The crude 2-allyl-4-(trifluoromethyl)phenol from Example 90 was dissolved in EtOH (5 mL), 10% Pd/C (20 mg) was added, and the mixture was stirred under an atmosphere of hydrogen at rt for 2 h. The catalyst was removed by filtration. The filtrate was concentrated under reduced pressure, and the residue was purified by silica gel flash chromatography (EtOAc/hexane (v/v) 1:10). This gave 91 mg (45% over 2 steps) of the title compound as a colorless oil. 1H NMR (400 MHz, CDCl3): δ 1.00 (t, 3H), 1.68 (m, 2H), 2.61 (t, 2H), 5.14 (br, 1H), 6.80 (d, 1H), 7.32 (d, 1H), 7.36 (s, 1H).

Quelle