Reaktion #69036

ord-cf4e3b74584149aeb41b3c78b6d7da5f

Reaktionsgleichung

O=C1c2ccccc2C(=O)N1CCS(=O)(=O)Cl
2-phthalimidoethanesulfonyl chloride
C1COCCN1
morpholine
→
O=C1c2ccccc2C(=O)N1CCS(=O)(=O)N1CCOCC1
2-(2-(morpholinosulfonyl)ethyl)isoindole-1,3-dione

Edukte

O=C1c2ccccc2C(=O)N1CCS(=O)(=O)Cl
2-phthalimidoethanesulfonyl chloride
C1COCCN1
morpholine

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigePrepared

Vorschrift

Prepared according to general method A from 2-phthalimidoethanesulfonyl chloride (2.0 g) and morpholine (2.14 ml). Yield: 1.28 g (48%). 1H-NMR (CDCl3) δ (ppm) 7.94-7.84 (m, 4H), 3.99 (t, J=6.8 Hz, 2H), 3.62 (t, J=4.7 Hz, 4H), 3.45 (t, J=6.8 Hz, 4H), 3.15 (t, J=4.6 Hz, 4H).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08530486B2uspto-grants-2013_09