Reaktion #68972

Reaktionsgleichung

water

1-(4-Bromophenyl)piperazine

triethylamine

methanesulfonyl chloride

→

1-(4-bromophenyl)-4-methanesulfonylpiperazine

Ausbeute 99.9%

Lösungsmittel

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturis maintained for 16 h
2. 2
   workup.STIRRINGstirring
3. 3
   Waschenthe organic phase is washed with a saturated aqueous sodium chloride solution
4. 4
   Trocknendried over MgSO4
5. 5
   Einengenconcentrated

Vorschrift

1-(4-Bromophenyl)piperazine (5 g, 20.7 mmol) is placed in 104 ml of dichloromethane and then triethylamine (4.34 ml, 31.1 mmol) is added, followed, dropwise, by methanesulfonyl chloride (1.93 ml, 24.9 mmol). Stirring is maintained for 16 h. After the addition of 30 ml of water and stirring, the organic phase is washed with a saturated aqueous sodium chloride solution, dried over MgSO4 and concentrated. 6.6 g of expected 1-(4-bromophenyl)-4-methanesulfonylpiperazine are obtained.

Quelle