Reaktion #68957

Reaktionsgleichung

5-(8-bromoisoquinolin-3-ylamino)pyrazine-2-carbonitrile

N-(2-aminoethyl)morpholine

→

title compound

5-(8-(2-morpholinoethylamino)isoquinolin-3-ylamino)pyrazine-2-carbonitrile

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethose described in Synthesis 5-1
2. 2
   Sonstigethe reaction at 140° C.

Vorschrift

The title compound was prepared using methods analogous to those described in Synthesis 5-1, replacing 3,8-dichloroisoquinoline with 5-(8-bromoisoquinolin-3-ylamino)pyrazine-2-carbonitrile and replacing (R)-5-amino-3-(pyrrolidin-3-yloxy)pyrazine-2-carbonitrile with N-(2-aminoethyl)morpholine, and conducting the reaction at 140° C.

Quelle