Reaktion #6894

Reaktionsgleichung

quinoline-2,6-diamine

product

2-piperidin-1-ylquinolin-6-amine

product

(2E)-3-(4-chlorophenyl)prop-2-enoyl chloride

→

(2E)-3-(4-chlorophenyl)-N-(2-piperidin-1-ylquinolin-6-yl)prop-2-enamide hydrochloride

Lösungsmittel

ether

HOAc

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe resulting mixture was filtered
2. 2
   Waschenthe resulting solids were washed with ether
3. 3
   SonstigeThe solids were dried under vacuum
4. 4
   Sonstigeto afford the product, MS

Vorschrift

To a solution of the product of Step D (91 mg, 0.4 mmol) in 2 mL HOAc was added the product of Step E (64 mg, 0.32 mmol). The resulting mixture was stirred at r.t. for 3 h then diluted with 3 mL ether. The resulting mixture was filtered and the resulting solids were washed with ether. The solids were dried under vacuum to afford the product, MS: m/z 392 (MH+), as an off-white solid. Using the appropriate starting materials and following procedures similar to those described above for Example 1, the following compounds were prepared from the corresponding quinoline-2,6-diamine intermediates:

Quelle