Reaktion #6892

Reaktionsgleichung

product

6-nitro-2-piperidin-1-ylquinoline

→

product

2-piperidin-1-ylquinolin-6-amine

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe resulting mixture was degassed
2. 2
   workup.DISSOLUTIONhad dissolved
3. 3
   FiltrationThe reaction mixture was filtered
4. 4
   Filtrationthrough filter aid
5. 5
   Sonstigethe solvent removed under vacuum

Vorschrift

The product (204 mg, 0.8 mmol) of Step C and palladium hydroxide on carbon (100 mg) was suspended in methanol. The resulting mixture was degassed then stirred under hydrogen atmosphere (balloon) until all the yellow solids had dissolved. The reaction mixture was filtered through filter aid and the solvent removed under vacuum to afford the product as a brown solid, MS: m/z 228 (MH+), which was used without further purification

Quelle