Reaktion #689178

Reaktionsgleichung

ethyl acetate

3-fluoro-5-methoxy-4-(2-propynyloxy)benzoyl chloride

2-methylcyclohexylamine

→

N-(2-methylcyclohexyl)-3-fluoro-5-methoxy-4-(2-propynyloxy)benzamide

Ausbeute 86.1%

Lösungsmittel

triethylamine

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe mixture obtained

Vorschrift

To a mixture of 5 ml of ethyl acetate and 0.30 g of 3-fluoro-5-methoxy-4-(2-propynyloxy)benzoyl chloride were added 0.15 g of 2-methylcyclohexylamine and 0.40 g of triethylamine in order at room temperature. The mixture obtained was stirred at room temperature for 2 hours. Then, the reaction product was subjected to silica gel column chromatography to obtain 0.34 g of N-(2-methylcyclohexyl)-3-fluoro-5-methoxy-4-(2-propynyloxy)benzamide (hereinafter, described as the compound 48 of the present invention) represented by the formula:

Quelle