Reaktion #689174

Reaktionsgleichung

3-fluoro-4-(2-propynyloxy)benzoyl chloride

2-methylcyclohexylamine

triethylamine

→

N-(2-methylcyclohexyl)-3-fluoro-4-(2-propynyloxy)benzamide

Ausbeute 93.1%

Lösungsmittel

ethyl acetate

ethyl acetate

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe mixture obtained
2. 2
   Filtrationthe mixture was filtered through Celite
3. 3
   EinengenThe filtrate was concentrated under reduced pressure
4. 4
   WaschenThe residue was washed in order with methyl tert-butyl ether and hexane

Vorschrift

To a mixture of 5 ml of ethyl acetate and 0.30 g of 3-fluoro-4-(2-propynyloxy)benzoyl chloride were added 0.19 g of 2-methylcyclohexylamine and 0.20 g of triethylamine in order at room temperature. The mixture obtained was stirred at room temperature for 1 hour. Then, ethyl acetate was added to the reaction mixture and the mixture was filtered through Celite. The filtrate was concentrated under reduced pressure. The residue was washed in order with methyl tert-butyl ether and hexane to obtain 0.38 g of N-(2-methylcyclohexyl)-3-fluoro-4-(2-propynyloxy)benzamide (hereinafter, described as the compound 34 of the present invention) represented by the formula:

Quelle