Reaktion #689166

Reaktionsgleichung

THF

3,5-dimethoxy-4-(2-propynyloxy)benzoyl chloride

2-methylcyclohexylamine

triethylamine

→

N-(2-methylcyclohexyl)-3,5-dimethoxy-4-(2-propynyloxy)benzamide

Ausbeute 83.7%

Lösungsmittel

ethyl acetate

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe mixture obtained
2. 2
   Filtrationthe mixture was filtered through Celite
3. 3
   EinengenThe filtrate was concentrated under reduced pressure
4. 4
   SonstigeThe residue obtained
5. 5
   Waschenwas washed with methyl tert-butyl ether and hexane

Vorschrift

To a mixture of 15 ml of THF and 0.45 g of 3,5-dimethoxy-4-(2-propynyloxy)benzoyl chloride were added 0.24 g of 2-methylcyclohexylamine and 0.27 g of triethylamine in order at room temperature. The mixture obtained was stirred at room temperature for 4 hours. Then, ethyl acetate was added to the reaction mixture and the mixture was filtered through Celite. The filtrate was concentrated under reduced pressure. The residue obtained was washed with methyl tert-butyl ether and hexane to obtain 0.49 g of N-(2-methylcyclohexyl)-3,5-dimethoxy-4-(2-propynyloxy)benzamide (hereinafter, described as the compound 19 of the present invention) represented by the formula:

Quelle