Reaktion #689162

Reaktionsgleichung

THF

3-methoxy-4-(2-propynyloxy)benzoyl chloride

2-methylcyclohexylamine

triethylamine

→

N-(2-methylcyclohexyl)-3-methoxy 4-(2-propynyloxy)benzamide

Ausbeute 89.4%

Lösungsmittel

ethyl acetate

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe mixture obtained
2. 2
   Filtrationwas filtered through Celite
3. 3
   EinengenThe filtrate was concentrated under reduced pressure

Vorschrift

To a mixture of 3 ml of THF and 0.3 g of 3-methoxy-4-(2-propynyloxy)benzoyl chloride were added dropwise 0.19 g of 2-methylcyclohexylamine and 0.16 g of triethylamine in order under ice cooling. The mixture obtained was stirred at room temperature for 4 hours. Then, ethyl acetate was added to the reaction mixture and it was filtered through Celite. The filtrate was concentrated under reduced pressure. The residue was subjected to silica gel column chromatography to obtain 0.36 g of N-(2-methylcyclohexyl)-3-methoxy 4-(2-propynyloxy)benzamide (hereinafter, described as the compound 2 of the present invention) represented by the formula:

Quelle