Reaktion #6886

Reaktionsgleichung

3-fluoroiodobenzene

4-methyl-1-(2-propynyl)piperidine

→

oil

Ausbeute 56.2%

1-[3-(3-Fluorophenyl)-2-propynyl]-4-methylpiperidine

Ausbeute 56.2%

Lösungsmittel

diethylamine

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwas heated
2. 2
   Temperaturunder reflux for 5 hours
3. 3
   SonstigeThe solvent was removed under reduced pressure
4. 4
   Waschenwashed with water
5. 5
   TrocknenThe organic phase was dried over magnesium sulfate
6. 6
   Sonstigethe solvent was removed under reduced pressure
7. 7
   workup.DISTILLATIONDistillation of the residue under reduced pressure

Vorschrift

A mixture of 3-fluoroiodobenzene (8.88 g), 4-methyl-1-(2-propynyl)piperidine (6.80 g), palladium acetate (0.045 g), tri-o-toloylphosphine (0.24 g) and copper(I) iodide (0.1 g) in dry diethylamine (50 ml) was heated under reflux for 5 hours. The solvent was removed under reduced pressure and the residue was taken up in diethyl ether and washed with water. The organic phase was dried over magnesium sulfate and the solvent was removed under reduced pressure. Distillation of the residue under reduced pressure gave an oil (5.20 g) of boiling point 105° C./0.07 mm Hg.

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