Reaktion #68852

Reaktionsgleichung

methyl magnesium bromide

2-methyl-propane-2-sulfonic acid 4-bromo-3-fluoro-benzylideneamide

THF

THF

→

N-[1-(4-Bromo-3-fluoro-phenyl)-ethyl]-acetamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe cooling bath is removed
2. 2
   workup.ADDITIONAfter that time, the mixture is poured into sat. NH4Cl-solution (300 mL)
3. 3
   Extraktionextracted with EtOAc

Vorschrift

Under inert gas atmosphere 37.2 mL (112 mmol) of a 3N solution of methyl magnesium bromide in THF are added dropwise to 17.1 g (55.8 mmol) 2-methyl-propane-2-sulfonic acid 4-bromo-3-fluoro-benzylideneamide (IX.1) in 170 mL THF at −78° C. The cooling bath is removed and stirring is continued for 2 h. After that time, the mixture is poured into sat. NH4Cl-solution (300 mL) and extracted with EtOAc.

Quelle