Reaktion #6885

Reaktionsgleichung

2-propynyl chloride

piperidine

→

1-(2-propynyl)piperidine

Lösungsmittel

methanol

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGThe mixture was stirred at 25° C. for 3 hours
2. 2
   Filtrationfiltered
3. 3
   EinengenThe filtrate was concentrated under reduced pressure
4. 4
   workup.DISTILLATIONthe residue was distilled (boiling point: 163–165° C./atmospheric pressure)

Vorschrift

With stirring, a solution of 2-propynyl chloride (40.31 g) in dry methanol (50 ml) was added dropwise to a solution of piperidine (92.14 g) in dry methanol (100 ml). The mixture was stirred at 25° C. for 3 hours and then filtered. The filtrate was concentrated under reduced pressure and the residue was distilled (boiling point: 163–165° C./atmospheric pressure).

Quelle