Reaktion #68849

Reaktionsgleichung

1-bromomethyl-2,2-difluorocyclopropane

K2CO3

2-chloro-5-hydroxypyrimidine

→

2-Chloro-5-((2,2-difluorocyclopropyl)methoxy)pyrimidine

Lösungsmittel

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThen the reaction mixture is quenched by the addition of water
2. 2
   Extraktionextracted with DCM
3. 3
   TrocknenThe organic layer is dried with Na2SO4
4. 4
   Sonstigethe solvent is removed in vacuo
5. 5
   SonstigeThe residue is purified by HPLC (MeOH/H2O/NH3)

Vorschrift

295 mg (1.72 mmol) 1-bromomethyl-2,2-difluorocyclopropane and 318 mg (2.30 mmol) K2CO3 are added to a mixture of 150 mg (1.15 mmol) 2-chloro-5-hydroxypyrimidine in 2 mL DMF. The mixture is stirred at 80° C. over night. Then the reaction mixture is quenched by the addition of water and extracted with DCM. The organic layer is dried with Na2SO4 and the solvent is removed in vacuo. The residue is purified by HPLC (MeOH/H2O/NH3).

Quelle