Reaktion #68841

Reaktionsgleichung

5-bromo-2-chloropyrimidine

sec-butylamin

ACN

→

5-Bromo-N-sec-butylpyrimidin-2-amine

Lösungsmittel

EtOAc

Reaktionsbedingungen

Aufarbeitung

1. 1
   Waschenwashed with water (2×)
2. 2
   Trocknenphase is dried with MgSO4
3. 3
   Sonstigethe solvent is removed in vacuo

Vorschrift

In a sealed tube 2.00 g (10.3 mmol) 5-bromo-2-chloropyrimidine and 3.13 mL (31.0 mmol) sec-butylamin are added to 12 mL ACN. The reaction mixture is stirred at 120° C. for 2 h, then diluted with EtOAc and washed with water (2×). The org. phase is dried with MgSO4 and the solvent is removed in vacuo. C8H12BrN3 (M=230.1 g/mol)

Quelle