Reaktion #68838

ord-2949511e5a7443a78404720baec74d54

Reaktionsgleichung

Oc1ccc(Br)cc1
4-bromophenol
ClCC1CC1
(chloromethyl)cyclopropane
O=C([O-])[O-].[K+].[K+]
K2CO3
CN(C)C=O
DMF
→
Brc1ccc(OCC2CC2)cc1
1-Bromo-4-cyclopropylmethoxybenzene

Edukte

Oc1ccc(Br)cc1
4-bromophenol
ClCC1CC1
(chloromethyl)cyclopropane
O=C([O-])[O-].[K+].[K+]
K2CO3
CN(C)C=O
DMF

Reagenzien

Keine

Lösungsmittel

O
water

Reaktionsbedingungen

Temperatur
80°CELSIUS
Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Extraktionextracted with DCM
  2. 2
    TrocknenThe organic layer is dried with MgSO4
  3. 3
    Sonstigethe solvent is removed in vacuo

Vorschrift

5.0 g (28.9 mmol) 4-bromophenol, 3.93 g (43.4 mmol) (chloromethyl)cyclopropane and 7.99 g (57.8 mmol) K2CO3 are added to 10 mL DMF and stirred at 80° C. over night. Afterwards the reaction mixture is diluted with water and extracted with DCM. The organic layer is dried with MgSO4 and the solvent is removed in vacuo.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08530460B2uspto-grants-2013_09